How Could Life Have Arisen on Earth? 

     Module written by Paul G. Jasien, Stanley L. Miller
     Matthew Levy, and Jason Dworkin

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    Session 1: How could life have arisen on earth?
    Introduction

      Exploration 1A: What are your initial ideas?
      Exploration 1B: What are the requirements of life?
      Exploration 1C: Where do we search for signs of life?

    Session 2: Under what conditions did life arise?
    The Primordial Environment

      Exploration 2A: What are your initial ideas?
      Oxidizing and Reducing Atmospheres

      Exploration 2B: What processes control the temperature of the earth?
      Energy Release and Absorption

      Exploration 2C: Can we make a simple model for the amount of O2 on the primitive earth?
      Steady State Processes

    Session 3: How can the molecules of life be made?
    The Building Blocks

      Exploration 3A: What are your initial ideas?
      Small Molecule Chemistry

      Exploration 3B: What do molecules look like in 3-D?
      Optical Isomers and Molecular Interactions

      Exploration 3C: Could life have arisen in space?

      Exploration 3D: Can we simulate the conditions of the early earth in the laboratory?
      High Energy Chemical Reactions

        Spark Discharge

      Exploration 3E: How can we simulate the origin of life on a computer?

    Session 4: What do we mean by a "stable" molecule?
    A Question of Time

      Exploration 4A: What are your initial ideas?

      Exploration 4B: Can a molecule be both stable and unstable?
      Thermodynamics and Stability

      Exploration 4C: Are amino acids "stable"?
      Concentration vs. Time Graphs

      Exploration 4D: How can we quantitate the rate of a reaction?
      Reaction Rates

    Session 5: Can life have arisen from a poison?
    Rate Laws

      Exploration 5A: What are your initial ideas?
      Concentration and reaction rates

        Variable Concentration Polymerization

      Exploration 5B: How can we mathematically represent the reaction rate?
      Rate Laws

      Exploration 5C: What could have happened in a tidal pool?
      Concentration Effects on Reaction Rates

      Exploration 5D: How can the rate law be determined?
      The Method of Initial Rates

      Exploration 5E: How can you find the rate law for the formation of adenine?
      Experimental Design and Rate Laws

      Exploration 5F: How can we relate rate laws to reaction mechanisms?
      Mechanisms and Rate Laws

    Session 6: How can prebiotic reaction rates be increased?
    Temperature and Rates

      Exploration 6A: What are your initial ideas?
      Temperature and Reaction Rates

        Variable Temperature Polymerization

      Exploration 6B: What molecular level model can account for reaction rate changes?
      Activation Energy and Chemical Reactions

      Exploration 6C: Could life have arisen at high temperature?
      The Arrhenius Equation

      Exploration 6D: How can certain molecules increase reaction rates?
      Catalysts and Chemical Reactions

      Exploration 6E: How can optical isomers be interconverted?

        Reaction Rate and Equilibrium

    Session 7: Can we determine when life arose?
    Kinetics and Nuclear Decay

      Exploration 7A: What are your initial ideas?
      Radioactive Elements

      Exploration 7B: Can we quantitatively analyze a first order reaction?
      First-Order Integrated Rate Law

      Exploration 7C: How can we find the age of rocks?
      Half-lives

    Session 8: How can we measure the rate of hydrolysis of cytosine to uracil in the laboratory?
    Mutations and Chemical Kinetics

      Experimental Determination of k and Ea

    Session 9: Putting it all together
    Where should we look for evidence of extraterrestrial life?


    Copyright © 2004 by the trustees of Beloit College and the Regents of the University of California. This Module has been developed under the direction of the ChemLinks Coalition, headed by Beloit College, and the ModularChem Consortium, headed by the University of California at Berkeley. This material is based upon work supported by the National Science Foundation grants No. DUE-9455918 and DUE-9455924. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation, Beloit College, or the Regents of the University of California.

    Published through exclusive license with W. W. Norton.
    How Could LIfe Have Arisen on Earth? ISBN 0-393-92436-X


    Origin of Life | ChemConnections