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Linus Pauling Meeting Notes   Sept, 2011 About the Linus Pauling Institute

This email is a teaser for longer notes here (if links do not work, go to http://chemistry.beloit.edu/Ordman/nutrition/aln/1109lpi.htm) from the Linus Pauling Meeting 2011, probably the best nutrition meeting on earth.  The Linus Pauling Institute is a great source for nutrition information, http://lpi.oregonstate.edu/infocenter/.  There are photos of me with Balz Frei, Bruce Ames, and other nutrition dignitaries.

Latest results about Resveratrol (Res)- Conclusion is that Res extends healthspan (which is consistent with the NPR report on the Nature paper). There were no hazardous side effects observed. Please read the longer summary here: http://chemistry.beloit.edu/Ordman/nutrition/aln/1109lpi.htm

PREGNANCY – 50% of C-sections are unnecessary. Infants born this way do not obtain Bifidobacteria infantis from the birth canal, a symbiotic bacteria essential to a healthy immune system and preventing obesity. Doctors can prescribe proper probiotics to prevent this.

ZINC – Even most ER doctors do not know that an immediate injection of lots o zinc will relieve sepsis almost immediately (Daren Koell, OSU)

PROBIOTICS – There are a hundred billion bacteria in your body, 90% of the cells in your body. They have 100xmore genes than your DNA, and the metagenome project investigates all of them, most of which are symbiotic. Prebiotics are fiber, probiotics are bacteria and yeast, and synbiotics include both. A low carb diet reduces healthful Lactobacillus and increases hazardous Clostridia in your colon. Soy is fermented to equol, an anticarcinogen. Fiber is converted by colon bacteria to butyrate that causes apoptosis (suicide) of cancer cells. Polyphenols from berries, walnuts, and wine, and lignans from flaxseed ferment in the colon into anticarcinogens. But obesity and antibiotics modify the colonic microbiota causing hazard. Eating at least a teaspoon of yogurt daily is great for everyone.

VITAMIN E - Vitamin E crosses the blood-brain barrier thanks to the alpha-tocopherol transport protein. Tocotrienols are the antioxidant of the 21st century. 400 iu of vitamin E daily blocks specific metabolic events that cause cancer, atherosclerosis, and chronic liver disease.

VITAMIN B3 – This is very useful to prevent and treat bacterial infections. Dose is about 10g vitamin B3 twice a day for an adult. Also it is an anti-inflammatory for psoriasis and eczema.

VITAMIN D-There are 2,700 binding sites for the vitamin D receptor complex that control gene expression on your DNA. These effects decrease infection, tuberculosis, cancer, and autoimmune diseases including Crohn’s. Pregnant women especially need vitamin D. Most are deficient in it. Children of deficient mothers have wheezing, and are more likely to have asthma. Please watch the VITAMIN D VIDEO. Most adults require 2,000 IU daily, but some need even more. Vitamin D causes production of CAMP, an antimicrobial peptide that prevents infections.

INFLUENZA – Get your flu shot, much more effective if you are taking at least 200iu of vitamin E regularly. Flu causes 30-90,000 deaths annually. Be sure to eat well when you have the flu.

SELENIUM – Supplements increase adverse reactions, esp. for diabetics

Broiling and frying of burgers and fries produce acrylamide and polycyclic amines that cause cancer. Best food preparation is steaming, next is microwaving, worst is pan frying in oil.

HOW TO EAT – A prudent diet like the Mediterranean (MED) or No Fours reduces your risk of heart disease 39%. A Western diet of red meat and French fries increases your risk 60%.

TRAUMA – Within 30 minutes of exposure to infectious bacteria, your microbiome secretes aggressive adhesin molecules to fight infection. People with Lactobacillus reuteri have half as many sick days. Gestational diabetes occurs in 36% of women, but only 13% of those who took an L. reuteri probiotic supplement.

LOSS OF HOMEOSTASIS WIH AGING - Curcumin delays this and slows Alzheimer's. Also vitamin D, flavones (in vegetables), are good. Lithium is useful for Parkinson's.

VITAMIN C (AA) AND CANCER- Mark Levine discussion - Intravenous AA is used to treat cancer patients. Giving 50 or 75g each time, 3 times per week, up to 20 times, dramatically increases the effectiveness of other chemotherapies. His patients experienced NO side effects from AA.

Alzheimer's disease (AD) - Antioxidants, B vitamins, omefga-3 fatty acids, and the Mediterranean Diet all delay it. Transfats substantially accelerate AD.

LIPOIC ACID - Taking supplements of Lipoic acid induces expression of Nrf2 gene, which is a transcription factor for 200 antioxidant-related genes.

At age 30, we start losing bone mass unless exercising. 50% of bone mass is made during adolescence. A 10% increase in peak bone mass delays osteoporosis 13 years and reduces fracture rate 50%, so get lots of exercise when young to increase peak bone mass. Most 18 year old girls do not get enough Ca+2.

MY VITAMIN C POSTER PRESENTATION is poster 168b at this link.

So there's the highlights of the meeting of the Linus Pauling Institute for Sept, 2011. Remember to be conscious of what you put in your body - like high self-esteem for learning about optimal nutrition! Till next time  ********Doc Roc, Nutritional Investigator

*To review the disclaimer. *To ask Nutrition Investigator (Roc) a question.
Roc Ordman for appointments or phoning pls email 24hrs ahead
Sabbatical until Jan, 2012
Professor, Biochemistry, Beloit College
http://chemistry.beloit.edu/Ordman out of office Thursdays
http://www.nutritioninvestigator.org

Thoreau's three truths: "that this earth is a garden of delights; that the world crowds round the individual, leaving him no vista, and shuts out the beauty of the earth; and that the wholesome wants of man are few."